mapk kinase kinase kinase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5643	NG25		MAPK
	NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.		MAPK
TQ0079	GNE-495		MAPK
	GNE-495 is a potent and specific MAP4K4 inhibitor (IC50: 3.7 nM).		MAPK
T15250	ETC-206		MNK
	ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).		MNK
T3468	Tomivosertib	eFT508	MNK , PD-1/PD-L1
	Tomivosertib (eFT508) is a potent, highly selective MNK1 and MNK2 inhibitor with IC50 value of 1-2 nM.		MNK , PD-1/PD-L1
T4011	NCB-0846	NCB 0846	MAPK , Wnt/beta-catenin
	NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).		MAPK , Wnt/beta-catenin
T16501	PF-3644022		p38 MAPK , Serine Protease , MAPK
	PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα production and has an anti-inflammatory effect. PF-3644022 also inhib...		p38 MAPK , Serine Protease , MAPK
T14988	CMPD1		MAPK
	CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).		MAPK
T11942	MAP4K4-IN-3	Compound 17	MAPK
	MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.		MAPK
T9470	HPK1-IN-7		MAPK
	HPK1-IN-7 is an orally active HPK1 inhibitor. It shows selectivity against IRAK4 (59 nM) and GLK (140 nM).		MAPK
T5483	DMX-5804	DMX-5084	MAPK
	DMX-5804 is a potent, selective MAP4K4 inhibitor, with an IC50 of 3 nM.DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice.		MAPK
T11438	GNE-1858		Others , MAPK
	GNE-1858 is an ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA).		Others , MAPK
T4424	SLV-2436	SEL-201,SLV 2436,SEL201-88	MNK
	SLV-2436 (SEL201-88) is a novel effective and ATP-competitive inhibitor of MNK1 and MNK2 (IC50: 10.8/5.4 nM).		MNK
T4221	PF-06260933	PF-6260933,PF 6260933,PF6260933	MAPK
	PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively.		MAPK
T6440	CGP 57380	MNK1 Inhibitor	Apoptosis , MNK
	CGP 57380 (MNK1 Inhibitor) is a potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases.		Apoptosis , MNK
T11793	KY-05009		Wnt/beta-catenin
	KY-05009 is a chemical compound that effectively suppresses TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells, reduces TNIK protein expression and the transcriptional activity o...		Wnt/beta-catenin
T12058	MK2-IN-3 hydrate	MK-2 Inhibitor III	ERK , MAPK , MNK
	MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)		ERK , MAPK , MNK
T9034	MK2-IN-3	MK2 Inhibitor III	MAPK
	MK2-IN-3 (MK2 Inhibitor III) is a potent, cell-permeable inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2 or MK-2) and can be used for the treatment of rheumatoid arthritis		MAPK
T4442	MK2-IN-1 hydrochloride	MK2 Inhibitor,MK 25	MAPK
	MK2-IN-1 hydrochloride (MK 25) is a highly selective, non-ATP competitive inhibitor of p38/mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2 or MK2, IC50: 0.11 μM) [1].		MAPK
T4645	TA-01		p38 MAPK , Casein Kinase , Autophagy
	TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.		p38 MAPK , Casein Kinase , Autophagy
T7196	HG-10-102-01		LRRK2
	HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).		LRRK2